Protective role of Nigella sativa oil against cisplatin-induced ototoxicity: a literature review

Cisplatin is widely used for the chemotherapy of head and neck cancer. However, it has a significant ototoxicity. Nigella sativa been scientifically proven to have numerous benefits included prevent adverse effect drug. This literature review aimed evaluate protective role N. oil against cisplatin-induced Relevant publications were searched from PubMed Google Scholar databases within last 10 years. Ototoxicity due cisplatin can occur through intrinsic extrinsic pathways. causes endoplasmic reticulum stress, DNA damage, increased reactive oxygen species (ROS) inflammatory processes, resulting in apoptosis cochlear outer hair cells. The active constituents including flavonoids, phenolics thymoquinone Examination endogenous antioxidants, antiapoptotic, proinflammatory could be as primary approach